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This is the second edition in five years of a brief introductory text in human cytogenetics. The book is explicitly written for clinicians without background in cytology. Accordingly, the first 44 of the 163 pages are devoted to basic cytogenetics (part 1), entitled "the grammar of cytogenetics." This part provides the background necessary for an understanding of the various cytogenetic anomalies encountered in pediatric practice. In this section, a slightly more detailed description of the different chromosome groups making up the normal karyotype would have been desirable. There is no mention of the Chicago nomenclature (1966), although this convenient shorthand notation is now widely used in publications, teaching, and reports from cytogenetic laboratories to the referring physicians. The use of the term "secondary non-disjunction" (p 39) in a context essentially unrelated to non-disjunction may be irritating to some geneticists for whom this term carries a different and more precise connotation,
PASSARGE E. The Chromosome Disorders: An Introduction for Clinicians. Am J Dis Child. 1970;120(3):283-284. doi:10.1001/archpedi.1970.02100080167033