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October 1970

Gonadal Dysgenesis in a Newborn With XO Karyotype

Author Affiliations

From the departments of pediatrics and pathology, University of Cincinnati, College of Medicine, Cincinnati.

Am J Dis Child. 1970;120(4):363-366. doi:10.1001/archpedi.1970.02100090137020

Few reports of karyotype-verified Turner's syndrome in neonates are available. This report is the third such case in which normal primordial follicles were not present in the ovary at the time of birth. In contrast, germ cells have been identified in all except one neonate with XO Turner's syndrome. These findings and the published data in XO embryos support the concept that developmental arrest at the stage of primordial follicle formation and subsequent regression of germinal structures is the most likely morphological basis for the ovarian dysgenesis which accompanies the XO state.