A 13-month-old infant developed acute tubular necrosis and deafness following the intramuscular administration of neomycin sulfate at a dose recommended only for oral use. The renal biopsy specimen revealed a characteristic vacuolization of the proximal tubular epithelium. The patient recovered from the acute renal insult with the maximum tubular secretory capacity for aminohippuric acid being the last renal function to return to normal. The hearing loss persisted.
De Beukelaer MM, Travis LB, Dodge WF, Guerra FA. Deafness and Acute Tubular Necrosis Following Parenteral Administration of Neomycin. Am J Dis Child. 1971;121(3):250-252. doi:10.1001/archpedi.1971.02100140116016