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May 1971

Congenital Ring Constrictions and Intrauterine Amputations

Author Affiliations

From the Department of Pediatrics, Baylor College of Medicine, Houston.

Am J Dis Child. 1971;121(5):393-400. doi:10.1001/archpedi.1971.02100160063006

Thirteen cases of amniogenic malformations of the extremities, an incidence of one per 10,000 live births, are reviewed. Characteristic clinical features were constriction rings and/or amputations, more commonly of digits, associated with clubfoot (31%), distal syndactyly (38.5%), and edema below a constriction ring (31%). Clinical and experimental evidence strongly suggests that the pathogenesis of these defects is related to early rupture of the amnion during gestation with subsequent encirclement of fetal extremities.