A diagnosis of neuroblastoma was made in two siblings, each at 5½ months of age. Both siblings are living and well, 2½ years and nine months, respectively, after surgery and x-ray therapy. The father had increased levels of 4-hydroxy-3-methoxymandelic acid (vanillylmandelic acid [VMA]) in his urine, but there was no clinical evidence of a neural tumor. The results of studies in this family suggest that neuroblastoma may be inherited in an autosomal dominant pattern after mutation of the genes governing the neural crest formation.
Wong K, Hanenson IB, Lampkin BC. Familial Neuroblastoma. Am J Dis Child. 1971;121(5):415-416. doi:10.1001/archpedi.1971.02100160085010