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June 1971

Treatment of Group A Streptococcal Pharyngitis in ChildrenComparison of Lincomycin and Penicillin G Given Orally and Benzathine Penicillin G Given Intramuscularly

Author Affiliations

Huntsville, Ala
Drs. Howie and Ploussard are in private practice in Huntsville, Ala.

Am J Dis Child. 1971;121(6):477-480. doi:10.1001/archpedi.1971.02100170059005

Two hundred twenty-eight children with group A β-streptococcal pharyngitis, or carrier state, were treated with one of three treatment regimes from September 1969 to March 1970 and followed-up with throat cultures at 5, 14, 31, and 60 days. Treatment groups were benzathine penicillin G given intramuscularly, and penicillin G potassium and lincomycin hydrochloride monohydrate, administered orally. Lincomycin hydrochloride monohydrate given orally in recommended dosages for ten days was found to be as effective as benzathine penicillin G given intramuscularly (cure rates at 31 days, 86.8% and 88.9%, respectively). Both drugs were more effective than penicillin G given orally for ten days (31-day cure rate, 70%). The 60-day cure rates were 84% for lincomycin given orally, 72% for benzathine penicillin G given intramuscularly, and 60% for penicillin G given orally.