Clinical, laboratory, and pathologic observations were made in a 9-year-old boy with sexual precocity and no significant neurological findings. X-ray films of the skull, brain scan, and examination of the cerebrospinal fluid were unremarkable. The correct diagnosis (hypothalamic tumor) was established only by pneumoencephalography. We believe that pneumoencephalography is mandatory in any boy with sexual precocity in whom a specific cause is not evident.
Hung W, Milhorat TH, Nelson KB, August GP, Cross LL. Sexual Precocity as the Only Sign of a Brain Tumor in a 9-Year-Old Boy. Am J Dis Child. 1971;121(6):524-527. doi:10.1001/archpedi.1971.02100170106018