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I much appreciate the opportunity to reply to the letters of Galant and Bullock and Crisp regarding my review of "Hyposensitization Therapy in Treatment of Allergic Disease." This series of comments will add significantly to the clarification of any misconception which may have arisen from my remarks, although I am not in the least sorry if the thoughts expressed in these remarks may have been found to be "disturbing."
The evidence for the value of injection therapy in the treatment of allergy, as presented by Sadan and others, is certainly quite convincing. However, those of us who have attempted to follow histamine release from basophils of patients treated in this manner will have to admit that the high values of histamine release which are necessary to quantitate reproducibly significant changes of these criteria following treatment are found only in a relatively small proportion of our patients, while the majority of
WITTIG HJ. HYPOSENSITIZATION THERAPY OF ALLERGIC DISEASES-Reply. Am J Dis Child. 1971;121(6):545. doi:10.1001/archpedi.1971.02100170125027