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Article
July 1971

Folate Metabolism in Erythroid Hyperplastic and Hypoplastic States

Author Affiliations

Washington, DC
From the Section of Hematology (Drs. Purugganan and Leikin) and the clinical laboratory (Miss Gautier), Children's Hospital of the District of Columbia; and Department of Pediatrics, George Washington University School of Medicine, Washington, DC.

Am J Dis Child. 1971;122(1):48-52. doi:10.1001/archpedi.1971.02110010084014
Abstract

Peripheral blood granulocyte lobe counts, serum and red blood cell folate, serum vitamin B12 levels, and formiminoglutamic acid (FIGLU) excretion studies were performed on patients with uncomplicated chronic hemolytic anemia, chronic hemolytic anemia associated with an aplastic crisis, and iron deficiency anemia with and without thrombocytopenia. Although diminished serum levels were found in half of the patients with an aplastic crisis, there was a lack of correlation between biochemical alterations and clincal course. Evidence of tissue folate deficiency was an infrequent finding in chronic hemolytic anemia and in iron deficiency anemia with or without thrombocytopenia.

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