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July 1971

Vaccination With RA 27/3 Rubella Vaccine

Author Affiliations

Berne, Switzerland; Marcy l'Etoile, France
From the Department of Virus Research, Institut Merieux, Marcy l'Etoile, France (Dr. Nicolas). Dr. Buser is in private pediatric practice in Berne, Switzerland.

Am J Dis Child. 1971;122(1):53-56. doi:10.1001/archpedi.1971.02110010089015

In order to further establish the safety of RA 27/3 vaccine and the quality of its antigenic response, both subcutaneous and intranasal administration of vaccine were studied. A contact study carried out in 70 families proved RA 27/3 vaccine to be noncontagious. The antibody response (hemagglutination-inhibition test) following vaccination, checked in 387 seronegative individuals, was only slightly inferior to that in individuals with preexisting naturally acquired antibodies. In children the failure rate was 7% when vaccine was administered intranasally and 0% when given subcutaneously. In adults, who were vaccinated only subcutaneously, 4% did not develop seroconversion. After three years, decline of the level of vaccine-induced antibodies was slightly faster than that of naturally immune individuals. In no instance was there loss of a significant titer. Negligible side reactions consisted in a few cases of slight indolent swellings of the nuchal glands. Rarely was a faint transient rash noted. No individual developed arthralgia or arthritis.