A child with Down's syndrome developed Hodgkin's sarcoma. Chromosomal analysis of an involved node demonstrated that the trisomy was of the 21-22 group, and the lymph node cells contained a number of chromosomal breaks and fragments. This case is another example of the association between Down's syndrome and the development of lymphoreticular malignancies.
McCormick DP, Meyer WJ, Nesbit ME. Coexistence of Hodgkin's Disease and Down's Syndrome. Am J Dis Child. 1971;122(1):71-73. doi:10.1001/archpedi.1971.02110010107021