July 1971

Coexistence of Hodgkin's Disease and Down's Syndrome

Author Affiliations

From the Department of Pediatrics, University of Minnesota Hospital, Minneapolis. Dr. McCormick is now with the United States Navy Medical Corps, Camp Lejeune, NC, and Dr. Meyer is now with the National Heart Institute, Bethesda, Md.

Am J Dis Child. 1971;122(1):71-73. doi:10.1001/archpedi.1971.02110010107021

A child with Down's syndrome developed Hodgkin's sarcoma. Chromosomal analysis of an involved node demonstrated that the trisomy was of the 21-22 group, and the lymph node cells contained a number of chromosomal breaks and fragments. This case is another example of the association between Down's syndrome and the development of lymphoreticular malignancies.