August 1971

Joint Complications Associated With Derivatives of HPV-77 Rubella Virus Vaccine

Author Affiliations

Salt Lake City
From the Division of Infectious Disease, Department of Medicine, University of Utah School of Medicine, Salt Lake City. At the onset of this study Dr. Spruance was an Epidemic Intelligence Service Officer for the Center for Disease Control, Public Health Service, and for the Utah State Division of Health.

Am J Dis Child. 1971;122(2):105-111. doi:10.1001/archpedi.1971.02110020039002

Joint symptoms associated with use of rubella virus vaccine, live attenuated HPV-77, in children have been reported to be infrequent and mild. Following a statewide rubella vaccination campaign in Utah, a survey of 4,919 children revealed a 9.9% incidence of joint symptoms following administration of HPV-77-dog kidney-12 vaccine. Significantly fewer joint reactions (4.6%) occurred following HPV-77-duck embryo 5 vaccine. The incidence of joint symptoms in unvaccinated controls was less than 1%. Seventy percent of those with joint symptoms following the dog kidney vaccine had pain for more than three days, and 49% reported limitation of motion of the involved extremity. Thirty-eight percent of these children cried because of the pain, and one in every five children missed time from school. Only one child in the survey population was hospitalized.