August 1971

Rubella Vaccine Responses and Other Viral Antibodies in Syracuse Children

Author Affiliations

Syracuse, NY
From the departments of pediatrics (Dr. Lamb) and preventive medicine (Drs. Lamb and Feldman), State University of New York, Upstate Medical Center, Syracuse.

Am J Dis Child. 1971;122(2):117-121. doi:10.1001/archpedi.1971.02110020051004

Rubella vaccine was administered to 289 preschool children in the winter and spring of 1969-1970. Among children with seronegative reactions, 94% acquired rubella hemagglutination-inhibition (HI) antibodies; 10 of the 13 who had remained negative responded with low titers to second doses of the same vaccine. Immunization histories were verified in over 85% of the children. Rubeola HI antibodies were present in 90% and those to mumps and vaccinia in 35% and 62%, respectively. Almost half had A2/HK/3/68 and A2/Jap/305/57 influenza antibodies. Poliovirus neutralizing antibodies were not detected to type 1 in 45% and to type 3 in 37%. The importance of maintaining continuing serological surveillance is emphasized by these data.