September 1971

Amino Acid-Hypertonic Glucose Treatment for Intractable Diarrhea in Infants

Author Affiliations

St. Louis; assisted in evaluation of the patients
From the Edward Mallinckrodt Department of Pediatrics (Dr. Keating) and the Mary Culver Department of Surgery (Dr. Ternberg), Washington University School of Medicine, St. Louis, the Division of Gastroenterology, St. Louis Children's Hospital (Dr. Keating), and the Division of Surgery, Barnes Hospital, St. Louis (Dr. Ternberg).

Am J Dis Child. 1971;122(3):226-228. doi:10.1001/archpedi.1971.02110030084009

Nine infants with intractable diarrhea and marasmus were fed intravenously with a crystalline amino acid-hypertonic glucose solution from 14 to 37 days. All recovered their ability to absorb all nutrients and are now normal without evidence of persistent underlying cause for diarrhea from 12 to 28 months later. This new technique represents an important form of therapy for this small but seriously ill group of infants. Two unusual complications of the therapy occurred.