September 1971

Treatment of Hepatic Coma With Exchange Transfusion

Author Affiliations

Santiago, Chile
From the Hospital Luis Calvo Mackenna, Santiago, Chile.

Am J Dis Child. 1971;122(3):229-231. doi:10.1001/archpedi.1971.02110030087010

Fourteen children with acute viral hepatitis and hepatic coma were treated by conservative methods (low-protein diet, corticosteroids, neomycin sulfate) and exchange transfusion. Eleven patients were in grade 4 of hepatic coma, the other three in grade 3. The clinical and laboratory data presented by these patients before the exchange transfusion are analyzed. Seven patients survived which amounts to 50% of the group. A long-term follow-up study of six of them showed normal liver function and, in four, normal histological appearance of the liver by biopsy.