October 1971

Severe Hypertension in Identical Twin Infants

Author Affiliations

From the Department of Pediatrics, University of Minnesota Hospitals, Minneapolis. Dr. Herdman is now with the Albany Medical College, New York State Kidney Disease Institute, Albany, NY. Dr. Fish is an Established Investigator of the American Heart Association. Dr. Good is an American Legion Memorial Research Professor of pediatrics and pathology.

Am J Dis Child. 1971;122(4):348-352. doi:10.1001/archpedi.1971.02110040132015

A set of identical female twins developed hematuria and a salt-losing state three days after birth. Evaluation at 10 months of age for failure to thrive revealed severe hypertension associated with interstitial nephritis and massive medial hypertrophy of the renal arterioles. Known causes of hypertension have been eliminated. To our knowledge, this clinical picture has not been previously described.