The concept of malignancy of the erythron was reexamined by characterization of erythropoiesis in a 6-year-old boy with erythroleukemia. Erythroblastic and myeloblastic activities were monitored with bone marrow and peripheral blood examinations at three-to four-week intervals for 21 months. Fluctuations in myeloblastic proliferation bore no relationship to the profile of erythroid proliferation. In contrast, a direct relationship between severity of anemia and magnitude of erythroid hyperplasia was demonstrated, and a physiologic relationship between serum erythropoietin and the hemoglobin concentration was observed. Though qualitatively abnormal, erythropoiesis in erythroleukemia is regulated by physiologic control mechanisms.
Roloff JN, Lukens JN. Dissociation of Erythroblastic and Myeloblastic Proliferation in Erythroleukemia. Am J Dis Child. 1972;123(1):11-13. doi:10.1001/archpedi.1972.02110070061004