February 1972

Normal Urine and Positive Immunofluorescence Reaction in Lupus Nephritis

Author Affiliations

From the Division of Nephrology, Children's Memorial Hospital (Dr. Ahmadian); and the Department of Pediatrics, Northwestern University Medical School (Drs. Given and Mendoza), Chicago. Dr. Mendoza is now with the Department of Pediatrics, University of California, San Diego, La Jolla, Calif.

Am J Dis Child. 1972;123(2):121-125. doi:10.1001/archpedi.1972.02110080099008

Four patients with systemic lupus erythematosus had normal findings of urinalysis and essentially normal renal function. Light microscopy studies of renal biopsy specimens revealed minimal abnormalities in three cases and early lupus nephritis in the fourth case. All four biopsy specimens had strongly positive immunofluorescence reaction with fluorescein isothiocyanate conjugated goat antihuman IgG and β1C globulin. Three of these patients later developed clinical signs of lupus nephritis in spite of treatment with steroids. This study indicates that positive immunofluorescence can be the earliest definite sign of renal involvement in systemic lupus erythematosus.