[Skip to Content]
[Skip to Content Landing]
Article
February 1972

IMIPRAMINE TREATMENT OF ENURESIS

Author Affiliations

Mineola, NY

Am J Dis Child. 1972;123(2):181. doi:10.1001/archpedi.1972.02110080159027
Abstract

To the Editor.—We should like to comment on the use of imipramine pamoate in the treatment of childhood enuresis.1

The case reports of toxic overdosage with this tricyclic anti-depressant tranquilizer appear to be increasing in direct proportion to the general use of this drug. Severe symptoms may occur after the ingestion of 10 mg/kg, inevitable severe symptoms with ingestion of 20 mg/kg, and the potential fatal dose in man is 40 mg/kg. A fatal outcome was reported in an 18-month-old child who ingested 14 tablets (350 mg).2-7

When physicians prescribe this medication, they should ensure that it is dispensed in a safety packaging device. Perhaps it should be reserved for the enuretic seriously disturbed by the problem.

First Page Preview View Large
First page PDF preview
First page PDF preview
×