Histologic examination of the liver in viral hepatitis concerns two main aspects: (1) the morphologic findings during the course of the disease and their prognostic value in severe jaundice; and (2) study of protracted forms ranging from simple persistent viral hepatitis to cirrhosis. Improved epidemiologic knowledge, the discovery of the Australia antigen (HAA) and, more recently, of epidemic-hepatitis-associated antigen (EHAA) by Costantino et al1 has provided a more precise etiological basis for study of the lesions. The results presented here concern the histological study of two homogeneous groups of patients: one of 28 patients with severe jaundice observed by Caroli and ourselves during an epidemic and another of 50 patients, with epidemic or serum hepatitis of variable duration, in a military hospital.
They represent 1% to 2% in most epidemics. Among 700 soldiers, most of them young adults, no deaths occurred. The classification into three main groups
Orcel L, Antoine HM, Smadja A. Pathological Findings in Viral Hepatitis. Am J Dis Child. 1972;123(4):291–299. doi:10.1001/archpedi.1972.02110100023008