July 1972

Hereditary Nephropathy With Nerve Deafness (Alport's Syndrome)

Author Affiliations

From the Division of Nephrology, Department of Paediatrics, Hospital for Sick Children, Toronto.

Am J Dis Child. 1972;124(1):84-88. doi:10.1001/archpedi.1972.02110130086013

The clinical, pathological, and genetic features of Alport's syndrome are presented and discussed with reference to seven families previously unreported. The commonly described features of hematuria, nerve deafness, progressive renal failure, and early death were observed. A close correlation of clinical and renal pathological changes was discovered. Evidence suggests that the primary lesion is glomerular, probably in the basement membrane, with progressive renal changes ensuing. Inheritance is most likely autosomal dominant with variable penetrance and expressivity. Implications in clinical pediatrics and genetic counseling are stressed.