July 1972

Down's Syndrome Associated With a Myeloproliferative Disorder

Author Affiliations

From the departments of medicine (Drs. Okada and Hoshino) and pathology (Drs. Liu and Yamamoto), Atomic Bomb Casualty Commission, and Hiroshima Citizens Hospital (Drs. Yamaoka and Murakami), Hiroshima. Dr. Hoshino is now with Kyoto University School of Medicine, Kyoto, Japan.

Am J Dis Child. 1972;124(1):107-110. doi:10.1001/archpedi.1972.02110130109018

A malignant myeloproliferative disorder occurred in a Japanese child with Down's syndrome. In addition to the features of acute myeloblastic leukemia, the patient demonstrated extensive megakaryocytic infiltrates in spleen, liver, lymph nodes, kidneys, and pancreas. The disturbance of bone marrow function in Down's anomaly may involve thrombopoiesis as well as granulopoiesis.