To the Editor.—To publish an article1 involving ampicillin treatment of group A streptococcal pharyngitis without mention of the irrationality of that drug for that clinical indication is reprehensible. I challenege the authors to present a single valid indication for ampicillin administration to a patient with presumed streptococcal sore throat. There is none. When ampicillin first became available idle curiosity to see what it would do against the Streptococcus might have been considered justification for a clinical trial, but the time has passed when one could condone such inappropriate investigation.
Perhaps some good will come from this paper: the rather high failure rate of ampicillin may discourage the deplorable and widespread practice of prescribing ampicillin for colds and sore throats.
NELSON JD. Streptococcal Pharyngitis Therapy. Am J Dis Child. 1972;124(4):610. doi:10.1001/archpedi.1972.02110160148020