Oral glucose tolerance tests on 24 children with achondroplasia showed glucose intolerance in 16 of them. They were also found to have significantly elevated levels of plasma free fatty acids after an overnight fast, which rose still higher following human growth hormone administration. Plasma insulin levels were normal, but growth hormone levels were significantly below normal at 8 am, and tended to remain low during the day. These data are consistent with the concept that children with achondroplasia have a defect in peripheral glucose utilization.
Collipp PJ, Sharma RK, Thomas J, Maddaiah VT, Chen SY. Abnormal Glucose Tolerance in Children With Achondroplasia. Am J Dis Child. 1972;124(5):682-685. doi:10.1001/archpedi.1972.02110170060008