Two brothers showed the typical clinical and radiographic changes of Morquio's disease, but with absence of keratosulfaturia. Marked variability of expression characterizes the findings in this condition, which we believe represents one of a heterogeneous group of heritable connective tissue disorders, manifested primarily by universal platyspondyly and variable mucopolysacchariduria. Longitudinal study of large numbers of cases and an international scheme of diagnosis and classification is recommended.
Norman ME, Pischnotte WO. Morquio's Disease. Am J Dis Child. 1972;124(5):719-722. doi:10.1001/archpedi.1972.02110170097016