November 1972

Morquio's Disease

Author Affiliations

Portsmouth, Va
From the Naval Hospital, Portsmouth, Va. Dr. Norman is currently with the Department of Pediatrics, University of Pennsylvania, and Laboratory of Clinical Immunology, The Children's Hospital of Philadelphia.

Am J Dis Child. 1972;124(5):719-722. doi:10.1001/archpedi.1972.02110170097016

Two brothers showed the typical clinical and radiographic changes of Morquio's disease, but with absence of keratosulfaturia. Marked variability of expression characterizes the findings in this condition, which we believe represents one of a heterogeneous group of heritable connective tissue disorders, manifested primarily by universal platyspondyly and variable mucopolysacchariduria. Longitudinal study of large numbers of cases and an international scheme of diagnosis and classification is recommended.