Two children had concomitant generalized hypotonia and maternal emotional deprivation. In each case, numerous tests of neuromuscular function were done to determine the cause of the hypotonia but no classifiable disease was found. Hypotonia began to resolve in each case when intensive substitute mothering was instituted.
Buda FB, Rothney WB, Rabe EF. Hypotonia and the Maternal-Child Relationship. Am J Dis Child. 1972;124(6):906-907. doi:10.1001/archpedi.1972.02110180108015