A 61/2-year-old black boy known to have sickle-cell anemia died shortly after developing sudden lethargy which progressed into unconsciousness. Bloodless spinal fluid suggested a diagnosis of cerebral thrombosis, but the postmortem examination revealed a massive subdural hemorrhage to be the cause of death. Although it is a rare complication, massive intracranial hemorrhage should be considered in the differential diagnosis in a child with sickle-cell anemia who shows acute neurological signs.
Falter ML, Sutton AL, Robinson MG. Massive Intracranial Hemorrhage in Sickle-Cell Anemia. Am J Dis Child. 1973;125(3):415-416. doi:10.1001/archpedi.1973.04160030073015