The activity of the phagocytosis stimulating peptide, tuftsin, was decreased in the serum of 18 of 23 splenectomized patients. Three of the splenectomized subjects with normal or near-normal tuftsin activity had had traumatic rupture of the spleen. Decreased tuftsin activity was also demonstrated in three patients with sickle-cell disease and in two adults with chronic granulocytic leukemia. Intermediate activity was measured in three patients with chronic lymphocytic leukemia and one patient with β-thalassemia.
Constantopoulos A, Najjar VA, Wish JB, Necheles TH, Stolbach LL. Defective Phagocytosis Due to Tuftsin Deficiency in Splenectomized Subjects. Am J Dis Child. 1973;125(5):663-665. doi:10.1001/archpedi.1973.04160050017004