This report presents four patients with acute lymphoblastic leukemia in whom severe back pain and associated x-ray evidence of vertebral compression and collapse, together with marked spinal osteoporosis, were the most striking initial findings. Back pain was alleviated when systemic remission was achieved by chemotherapy. In no case was specific therapy directed toward the spinal lesions and symptomatic improvement was not reflected by x-ray evidence of healing.
Newman AJ, Melhorn DK. Vertebral Compression in Childhood Leukemia. Am J Dis Child. 1973;125(6):863-865. doi:10.1001/archpedi.1973.04160060065015