A 14-month-old girl with chorioretinitis, patent ductus arteriosus, short digits with deformed nails, and growth and developmental retardation is described. Bullous lesions were present at birth and bouts of fever and vesicular skin lesions recurred periodically. Herpesvirus was cultured from the vesicular lesions and the patient's antibody response indicated infection with herpesvirus type II. It is postulated that the infection occurred in utero, produced the anomalies, and persisted to cause the recurring episodes of illness.
Montgomery JR, Flanders RW, Yow MD. Congenital Anomalies and Herpesvirus Infection. Am J Dis Child. 1973;126(3):364-366. doi:10.1001/archpedi.1973.02110190322017