November 1973

Mediastinal Teratoma With Endocrine Function

Author Affiliations

Rochester, NY
From the departments of pediatrics (Dr. Honicky) and pathology (Dr. dePapp), University of Rochester (NY) School of Medicine and Dentistry. Dr. Honicky is now with Boston City Hospital.

Am J Dis Child. 1973;126(5):650-653. doi:10.1001/archpedi.1973.02110190522012

An insulin-producing teratoma of the mediastinum was found in a 5-year-old boy. Asymptomatic hypoglycemia and an elevated plasma level of immunoreactive insulin were noted preoperatively. After removal of the teratoma, which contained an abundance of islet cell tissue, both of these values returned to normal. This is, to our knowledge, the first report of a benign teratoma with such endocrine activity.