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December 1973

Idiopathic Gynecomastia in Seven Preadolescent BoysElevation of Urinary Estrogen Excretion in Two Cases

Author Affiliations

From the Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh.

Am J Dis Child. 1973;126(6):771-773. doi:10.1001/archpedi.1973.02110190621006

Gynecomastia was bilateral in five of seven prepubertal boys. Onset was between 2½ and 7½ years of age in five patients and was present from birth in another. Urinary estrogen excretion was increased in two patients. In six patients the condition was selflimited; one boy required mastectomy and the histopathological picture was that of dense fibrocollagenous and adipose stromacontaining ducts. In two instances, there was a family history of the condition in males.