December 1973

Management of Chédiak-Higashi Syndrome With Transfer Factor

Author Affiliations

From the departments of immunotherapy (Dr. Khan) and hematology (Drs. Hill, Loeb, MacLellan, and Hill) of the Wadley Institutes of Molecular Medicine, and the Granville C. Morton Cancer and Research Hospital, Dallas.

Am J Dis Child. 1973;126(6):797-799. doi:10.1001/archpedi.1973.02110190643012

A 1-year-old white girl with typical signs and symptoms of Chédiak-Higashi syndrome showed impaired delayed hypersensitivity. The patient had frequent upper respiratory tract infections in the past, including an attack of viral pneumonia. Transfer factor prepared from 2 × 108 normal lymphocytes was given intramuscularly. Following this, the patient developed delayed hypersensitivity responses. Passive transfer of histoplasmin reactivity from the donor to the recipient was also accomplished. The patient exhibited evidence of improved immunity.