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December 1973

Ménétrier Disease and Cytomegalovirus Infection in Childhood

Author Affiliations

Kansas City, Mo
From the departments of radiology (Dr. Leonidas), pathology (Dr. Beatty), and pediatrics (Dr. Wenner), Children's Mercy Hospital and the University of Missouri, Kansas City.

Am J Dis Child. 1973;126(6):806-808. doi:10.1001/archpedi.1973.02110190648013

Cytomegalic inclusions, characteristic of infection with cytomegalovirus, were found in the hypertrophic gastric mucosa of a 3½-year-old child with giant hypertrophic gastritis and protein loss in the gastrointestinal tract (Ménétrier disease). There was a tardy 16-fold rise of complement fixation titers against cytomegalovirus soon after the acute phase of the illness. To our knowledge, the association of Ménétrier disease and cytomegalovirus has been reported only once before.