To the Editor.—I want to comment on the article "Massive Virginal Breast Hypertrophy" by Hollingsworth and Archer (Am J Dis Child 125:293-295, 1973). These authors describe a 14-year-old girl with massive bilateral hypertrophy of the breasts, and describe a number of laboratory investigations, including data consistent with mild hypothyroidism.
However, there is no mention of Cowden disease, which was described by Lloyd and Dennis some ten years ago.1 Their patient had the following findings: (1) adenoid facies, (2) hypoplasia of mandible and maxilla, (3) high-arched palate, (4) hypoplasia of soft palate and vulva, (5) microstomia, (6) papillomatosis of lips and oral pharynx, (7) scrotal tongue, (8) multiple thyroid adenomas, (9) bilateral virginal hypertrophy of breasts with advanced fibrocystic disease and early malignancy, (10) pectus excavatum, (11) scoliosis, (12) space-occupying lesions in liver and bone, (13) abnormalities of central nervous system, and (14) history of a forme fruste of the
HANDLER H. Breast Hypertrophy. Am J Dis Child. 1973;126(6):860. doi:10.1001/archpedi.1973.02110190702027