December 1973

Cytomegalovirus Infection and Toxoplasma

Author Affiliations

Department of Pathology and Oncology School of Medicine University of Kansas Medical Center Rainbow Boulevard at 39th Street Kansas City, KS 66103

Am J Dis Child. 1973;126(6):860-861. doi:10.1001/archpedi.1973.02110190702029

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To the Editor.—I reviewed sections from the lung of the stillborn baby with cytomegalovirus infection (CMV), the report of which was published by Demian et al in the Journal (125:420-421, 1973). The authors kindly drew circles around more than 11 cells containing supposed double infections involving CMV and Toxoplasma. However, in my opinion, all the cytoplasmic inclusions are those of CMV. This report, and others (JAMA 198:203, 1966) indicate that intranuclear inclusions of CMV are recognized, but that cytoplasmic inclusions are sometimes misinterpreted as Toxoplasma. Numerous publications have recognized both types of inclusions, and the viral nature of the cytoplasmic inclusions is confirmed by ultrastructural studies, such as that by McGavin and Smith (Exp Mol Pathol 4:1-10, 1965) and Luna and Lichtiger (Am J Clin Pathol 55:499-505, 1971). Double infections of cultured cells have been produced experimentally (Nature 220:299-300, 1968; Science 160:1130-1132, 1968). In the latter publication, the difference

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