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February 1974

The Tricho–Rhino–Phalangeal Syndrome

Author Affiliations

From the Center for Genetics, Center for Craniofacial Anomalies, and the departments of dermatology (Dr. Solomon), pediatrics (Dr. Pashayan), and radiology (Dr. Chan), University of Illinois at the Medical Center, Chicago.

Am J Dis Child. 1974;127(2):257-261. doi:10.1001/archpedi.1974.02110210107016

A family of three children exhibited the tricho-rhino-phalangeal (TRP) syndrome. The father showed the characteristic facial features and microscopic evidence of scanty and fine hair, but no roentgenographic evidence of abnormal phalanges. The mother, in turn, showed no clinical evidence of having the syndrome, but she did show roentgenographic evidence of phalangeal dysplasia.

It is postulated that this family shows the autosomal dominant type of the TRP syndrome with father-to-son transmission.