Percutaneous renal biopsy in a child with nephrotic syndrome was followed by copious oozing of a clear, oily liquid from the skin puncture site. Subsequently, inflamed subcutaneous nodules appeared over the trunk and extremities suggesting Weber-Christian panniculitis. Extensive liquefication of fat occurred, especially over the abdomen, hips, and scrotum. Attacks of panniculitis subsided in nine months. The child received an eight-week therapy with cyclophosphamide and prednisone, and has remained free of proteinuria for one year.
Srivastava RN, Mayekar G, Anand R, Roy S. Weber-Christian DiseaseWith Nephrotic Syndrome. Am J Dis Child. 1974;127(3):420–421. doi:10.1001/archpedi.1974.02110220118018