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March 1974

Weber-Christian DiseaseWith Nephrotic Syndrome

Author Affiliations

New Delhi
From the departments of pediatrics (Drs. Srivastava, Mayekar, and Anand) and pathology (Dr. Roy), All India Institute of Medical Sciences, New Delhi.

Am J Dis Child. 1974;127(3):420-421. doi:10.1001/archpedi.1974.02110220118018

Percutaneous renal biopsy in a child with nephrotic syndrome was followed by copious oozing of a clear, oily liquid from the skin puncture site. Subsequently, inflamed subcutaneous nodules appeared over the trunk and extremities suggesting Weber-Christian panniculitis. Extensive liquefication of fat occurred, especially over the abdomen, hips, and scrotum. Attacks of panniculitis subsided in nine months. The child received an eight-week therapy with cyclophosphamide and prednisone, and has remained free of proteinuria for one year.