March 1974

Pharmacologic Management of Childhood Asthma

Author Affiliations

Department of Pediatric Allergy National Jewish Hospital & Research Center Department of Pediatrics University of Colorado

Am J Dis Child. 1974;127(3):442. doi:10.1001/archpedi.1974.02110220140022

To the Editor.—We would like to comment on the excellent review by Drs. Chai and Newcomb that appeared in the Journal (125:757, 1973). Our comment is in regard to their recommendation that "zoster immune globulin be administered to all children who are exposed to varicella while receiving corticosteroids." The basis for this recommendation is a letter to the editor that appeared in the Journal of Pediatrics,1 reporting death in two boys treated with steroids for acute rheumatic fever who developed fulminant fatal varicella. Reference 2 of this letter referred to our report2 in which we suggested that varicella did not pose a hazard for children receiving steroid therapy of the order usually necessary to achieve acceptable control of asthma, namely, 5 to 15 mg of prednisone per day, a view contrary to that held at that time. Our finding was subsequently supported by other authors. Furthermore, recent experience

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