Sequential serum samples from 100 children with documented group A streptococcal pharyngitis treated with orally given penicillin were examined with antistreptolysin and Streptozyme tests.
The Streptozyme test was positive with all sera with antistreptolysin titers [unk] 166 Todd units. Serum samples showing low antistreptolysin and elevated Streptozyme titers had an increased antihyaluronidase or antideoxyribonuclease B titer, or both, in more than 50% of the cases.
Patients with low initial antistreptolysin and Streptozyme titers, on reexamination one month later, exhibited statistically significant titer increase. These levels, however, still remained below the accepted "normal" levels.
Silverman BK, Bierman RH, Atkin D, Katz NS, Janeff JD, Janeff DG. Comparative Serological Changes Following Treated Group A Streptococcal Pharyngitis. Am J Dis Child. 1974;127(4):498–501. doi:10.1001/archpedi.1974.02110230044006