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June 1974

Human RabiesDiagnosis, Complications, and Management

Author Affiliations

Oakland, Calif
From the University of California at Los Angeles Hospital (Dr. Bhatt); Children's Hospital Medical Center, Oakland, Calif (Dr. Gerdsen); Respiratory and Special Pathogens Branch, Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control, Atlanta (Dr. Hattwick); and Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley (Drs. Emmons and Johnson).

Am J Dis Child. 1974;127(6):862-869. doi:10.1001/archpedi.1974.02110250088013

A 6-year-old boy developed rabies 71 days after he was bitten by a dog, and died 27 days later. Intensive supportive medical treatment prolonged the clinical course, which was complicated by apnea, cardiac arrest, hypotension, inappropriate secretion of antidiuretic hormone, and diabetes insipidus. The diagnosis of rabies was confirmed by virus isolation and rising antibody titers prior to death and by virus isolation and fluorescent antibody staining of brain tissue at autopsy.