A family had tetralogy of Fallot and right aortic arch in three successive generations. While the inheritance pattern of the cardiac lesion does not appear to follow classical mendelian genetics, genetic factors have certainly played a role in the familial aggregation of tetralogy in this family.
Friedberg DZ. Tetralogy of Fallot With Right Aortic Arch in Three Successive Generations. Am J Dis Child. 1974;127(6):877-878. doi:10.1001/archpedi.1974.02110250103016