The cure rate in children treated for β-hemolytic streptococcal pharyngitis with erythromycin estolate (Ilosone) administered twice daily (85%) was not significantly different from that in children treated with the same drug (92%), penicillin phenoxymethyl (88%), or clindamycin palmitate (92%) administered three times daily.
Breese BB, Disney FA, Talpey W, Green JL, Tobin J. Streptococcal Infections in ChildrenComparison of the Therapeutic Effectiveness of Erythromycin Administered Twice Daily With Erythromycin, Penicillin Phenoxymethyl, and Clindamycin Administered Three Times Daily. Am J Dis Child. 1974;128(4):457–460. doi:10.1001/archpedi.1974.02110290027005