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October 1974

Clinical Manifestations of Coxsackievirus Infections in Children

Author Affiliations

From the departments of pediatrics (infectious diseases) and microbiology, Montreal Children's Hospital; and McGill University-Montreal Children's Hospital Research Institute.

Am J Dis Child. 1974;128(4):464-468. doi:10.1001/archpedi.1974.02110290034006

Coxsackievirus B infection was proved by virus isolation or rise in virus titer in 26 children during 1972 at the Montreal Children's Hospital. Sixty-nine percent of these infections occurred during July and August. The spectrum of illness associated with the five implicated coxsackievirus B serotypes included gastroenteritis, pleurodynia, pharyngitis, meningitis, and pericarditis. Lower-respiratory tract infection, transverse myelitis, and an infectious mononucleosis-like syndrome were also seen, and coxsackievirus B1 was isolated from a lymphosarcoma. This experience emphasizes the need for appropriate viral studies in determining the cause of childhood illnesses suspected of being infectious in origin.