Coxsackievirus B infection was proved by virus isolation or rise in virus titer in 26 children during 1972 at the Montreal Children's Hospital. Sixty-nine percent of these infections occurred during July and August. The spectrum of illness associated with the five implicated coxsackievirus B serotypes included gastroenteritis, pleurodynia, pharyngitis, meningitis, and pericarditis. Lower-respiratory tract infection, transverse myelitis, and an infectious mononucleosis-like syndrome were also seen, and coxsackievirus B1 was isolated from a lymphosarcoma. This experience emphasizes the need for appropriate viral studies in determining the cause of childhood illnesses suspected of being infectious in origin.
Dery P, Marks MI, Shapera R. Clinical Manifestations of Coxsackievirus Infections in Children. Am J Dis Child. 1974;128(4):464-468. doi:10.1001/archpedi.1974.02110290034006