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October 1974

Biological and Environmental Determinants of Early Development,

Author Affiliations

Department of Pediatrics University of Rochester 260 Crittenden Blvd Rochester, NY 14642


edited by John I. Nurnberger, 457 pp, 111 illus, $31.50, Williams & Wilkins Co, 1973.

Am J Dis Child. 1974;128(4):585-586. doi:10.1001/archpedi.1974.02110290155032

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I found this an exciting book, not so much because of any breakthroughs in our understanding of child development, but because of the broad look at development that it encompasses in traveling from the subcellular level to the body politic. Equally fascinating is that no matter at which end of this spectrum one begins, the underlying theme of "structure leads to function leads to behavior" appears to apply equally well.

A number of chapters deal with the effects of various biological insults on the developing nervous system and the methods available to study them, such as staining techniques, tissue culture, and the use of enzyme markers. There is a good review of "Drugs in Pregnancy and Their Effects on Pre- and Postnatal Development" by Kelsey, with an interesting observation that nurses working in operating rooms have a higher rate of miscarriage, suggesting a relationship to the anesthetic agents being used

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