Colorectal cancer in young people has a poor prognosis because of presumed inherent biologic aggressiveness, but also because of failure to suspect the lesion early in its clinical course. Two adolescents with long-standing carcinoma of the rectum were treated at the University of Virginia Medical Center. Both had been treated for presumed benign anorectal disease for a prolonged period of time prior to referral.
Golden GT, Rosenthal JD, Shaw A. Carcinoma of the Rectum in Adolescence. Am J Dis Child. 1975;129(6):742-743. doi:10.1001/archpedi.1975.02120430074020