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Article
March 1976

Abnormal Collagen in Ataxia Telangiectasia

Author Affiliations

From the departments of pediatrics (Drs McReynolds, Hanissian, Kimbrell, and Duenas) and biochemistry (Dr Dabbous), University of Tennessee Medical Units, Memphis.

Am J Dis Child. 1976;130(3):305-307. doi:10.1001/archpedi.1976.02120040083016
Abstract

• Ataxia telangiectasia has been associated with varying clinical and laboratory abnormalities of the cutaneous, immune, neurological, and endocrine systems. Recently, a primary defect in tissue differentiation has been proposed as a probable cause of the disease. The presence of biochemically abnormal collagen in the skin of two siblings with the disease may further support this hypothesis.

(Am J Dis Child 130:305-307, 1976)

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