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April 1976

Epidermodysplasia Verruciformis

Author Affiliations

From the Division of Dermatology and the Department of Pathology, University of Texas Southwestern Medical School, Dallas. Dr Prystowsky is now with the Division of Dermatology Research, Letterman Army Institute of Research, Presidio of San Francisco.

Am J Dis Child. 1976;130(4):437-440. doi:10.1001/archpedi.1976.02120050095019

• Epidermodysplasia verruciformis (EV) is characterized by the early onset of extensive, persistent verruca plana that may undergo malignant transformation. Immunologic studies of a case of EV confirmed by electron microscopic identification of the virus disclosed no detectable abnormalities. The importance of this uncommon clinical syndrome lies in its demonstration that benign papovavirus, the etiologic agent of warts, can produce malignant neoplasms in genetically susceptible hosts.

(Am J Dis Child 130:439-440, 1976)