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August 1976

Hyperuricemia in the Hemolytic-Uremic Syndrome

Author Affiliations

From the Department of Nephrology, McGill University-Montreal Children's Hospital Research Institute, Montreal (Dr Kaplan), and the Department of Pediatrics, Transvaal Memorial Hospital for Children and University of the Witwatersrand, Johannesburg, South Africa (Dr Thomson).

Am J Dis Child. 1976;130(8):854-856. doi:10.1001/archpedi.1976.02120090064011

• Elevated serum uric acid concentrations were found in 18 children with hemolytic-uremic syndrome. The highest recorded level in each patient ranged from 10 to 29 mg/100 ml, and nine patients had concentrations of greater than 20 mg/100 ml. During a 53-hour period of peritoneal dialysis, 5.5 gm of uric acid was removed from one infant. Although acute renal failure was probably the major factor, erythrocyte destruction and hyperlacticacidemia may also have been important in the pathogenesis of the hyperuricemia.

(Am J Dis Child 130:854-856, 1976)