March 1977

The Atrial Septal Defect-Patent Ductus Arteriosus Complex

Author Affiliations

From the Willis J. Potts Children's Heart Center, Children's Memorial Hospital, and the Department of Pediatrics, Northwestern University Medical School (Drs Cole, Lawson, Newfeld, and Paul), and the Congenital Heart Disease Research and Training Center, Hektoen Institute for Medical Research (Drs Bharati and Lev), Chicago.

Am J Dis Child. 1977;131(3):281-285. doi:10.1001/archpedi.1977.02120160035004

• Both atrial septal defect and patent ductus arteriosus are common isolated lesions, each accounting for approximately 10% of the total incidence of congenital heart disease. Yet, the combination of these defects, without other significant cardiac lesions, is infrequent. We review the clinical and pathologic data on 16 patients with this combination of defects, including cardiac catheterization data on eight patients. In patients with this combination, we found an unusually high incidence of severe pulmonary hypertension, multiple noncardiac anomalies, mental retardation, and early mortality.

(Am J Dis Child 131:281-285, 1977)